Increased SIAH expression predicts ductal carcinoma in situ (DCIS) progression to invasive carcinoma
نویسندگان
چکیده
منابع مشابه
Ductal carcinoma in situ (DCIS) in Karachi.
OBJECTIVE To study the frequency of ductal carcinoma in situ (DCIS) in a large pathology series. DCIS is a proliferation of non-invasive, malignant epithelial cells within the ductolobular system of the breast. It is a heterogeneous entity with several morphologic variants that differ in gross appearance, growth pattern, cytologic features, mammography, and malignant potential. METHODS The da...
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Background: The breast cancer is the most prevalent cancer among women, on the other hand absence of myoepithelial cells play a pivotal role in pathogenesis of this cancer. Thus we aimed to investigate the possible abilities of the molecular assay technique to find a relationship between mammary serine protease inhibitor (Maspin) gene expression possibly secreted by my...
متن کاملSOX11 promotes invasive growth and ductal carcinoma in situ progression
Here, we show that SOX11, an embryonic mammary marker that is normally silent in postnatal breast cells, is expressed in many oestrogen receptor-negative preinvasive ductal carcinoma in situ (DCIS) lesions. Mature mammary epithelial cells engineered to express SOX11 showed alterations in progenitor cell populations, including an expanded basal-like population with increased aldehyde dehydrogena...
متن کاملMedullary Breast Carcinoma and Invasive Ductal Carcinoma: A Review Study
Background: Medullary breast carcinoma (MBC) is a unique histological subtype of breast cancer. The present study aimed to evaluate the classic and non-classic characteristics of MBC and its differences with IDC. The present review study incorporates 22 years of practical experience from a breast disease research center-based series of cases.Methods: Retrospectively, the medical records of 3,24...
متن کاملDiagnosis and management of ductal carcinoma in situ (DCIS).
OBJECTIVES Systematic synthesis of the published evidence about incidence, risk factors, and management options for women with ductal carcinoma in situ (DCIS) of the breast. DATA SOURCES Original epidemiologic studies were sought from several databases to identity articles published in English between 1970 and January 31, 2009. REVIEW METHODS Incidence of DCIS in the general population and ...
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ژورنال
عنوان ژورنال: Breast Cancer Research and Treatment
سال: 2010
ISSN: 0167-6806,1573-7217
DOI: 10.1007/s10549-010-1254-8